Silk Based Drug Delivery Systems

Author : Elia Bari
Publisher : Royal Society of Chemistry
ISBN 13 : 1839162678
Total Pages : 243 pages
Book Rating : 4.71/5 ( download)

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Download or read book Silk-based Drug Delivery Systems written by Elia Bari and published by Royal Society of Chemistry. This book was released on 2020-10-05 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Silk proteins show excellent biocompatibility, controllable biodegradability and non-immunogenicity, and as such are studied extensively worldwide for biomedical applications. In particular, there is increasing interest in their use for drug delivery systems. This focussed book on silk proteins for drug delivery systems, delves into a key emerging area to outline the concepts and define the field. Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin. Showing how these proteins are employed in micro and nano drug delivery systems, their use in pre-clinical and clinical trials, and closing with chapter on sustainability- driven innovation in the pharma industry, this book is ideal for graduates and researchers in biomaterials science and pharmaceutical science.

Author : Stroeve Pieter
Publisher : World Scientific
ISBN 13 : 9813201061
Total Pages : 392 pages
Book Rating : 4.64/5 ( download)

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Download or read book Drug Delivery Systems written by Stroeve Pieter and published by World Scientific. This book was released on 2017-11-27 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the alarming increase in cancer diagnoses and genetic illnesses, traditional drug agents and their delivery media need to be re-evaluated to address a quickly evolving field. With newer smart materials for the controlled release of macromolecules, peptides, genetic material, etc. further complications arise, such as material performance, synthesis, functionalization and targeting, biological identity, and biocompatibility. The book provides a comprehensive overview of the recent developments on "smart" targeting and drug delivery systems with a variety of carriers like nanoparticles, membranes, and hydrogels. It contains detailed descriptions on the recent trends in this field in the ongoing battle with catastrophic diseases like cancer. This field of research has been in its infancy and continues to face growth, and with it, further challenges and difficulties along the way toward maturity, which are accurately introduced in this book. Contents: Drug Delivery Systems: Possibilities and Challenges (Ryan Spitler, Saeid Zanganeh, Tahereh Jafari, Nasser Khakpash, Mohsen Erfanzadeh, Jim Q Ho, and Nastaran Sakhaie)Nanoparticles in Circulation: Blood Stability (Saeid Zanganeh, Tahereh Jafari, Nasser Khakpash, Mohsen Erfanzadeh, and Jim Q Ho)How do Nanoparticles (NPs) Pass Barriers? (Saeid Zanganeh, Ryan Spitler, Najme Javdani, and Jim Q Ho)Gated Porous Materials for Biomedical Application (Félix Sancenón, Erick Yu, Elena Aznar, M Dolores Marcos, and Ramón Martínez-Máñez)Controlled Release from Iron Oxide Nanoparticles (Masoud Rahman)The Reverse of Controlled Release: Controlled Sequestration of Species and Biotoxins into Nanoparticles (NPs) (Jenifer Gómez-Pastora, Eugenio Bringas, María Lázaro-Díez, José Ramos-Vivas, and Inmaculada Ortiz)Membranes for Controlled Release (Vida Araban, Neda Aslankoohi, and Mohammad Raoufi)Controlled Released from Hydrogel (Hossein Riahinezhad, Vida Araban, and Mohammad Raoufi)Nano Delivery Systems (Sophie Laurent, Afsaneh Lahooti, Saeed Shanehsazzadeh, and Robert N Muller)Legal Framework for Protection of Pharmaceutical Trade Marks in Europe and USA (Mohammad Hossein Erfanmanesh, and Shirin Sharifzadeh)Future Perspective on the Smart Delivery of Biomolecules (Erick Yu, Félix Sancenón, Elena Aznar, Ramón Martínez-Máñez, María Dolores Marcos, Mohammad J Hajipour, Morteza Mahmoudi, and Pieter Stroeve) Readership: Nanotechnologists; biomedical engineers; chemical engineers; materials scientists; biotechnology researchers; chemists; biological scientists; cell physiologists; medical scientists; gene therapists. Keywords: Drug Delivery Systems;Nanoparticles;Biomaterials;TargetingReview: Key Features: Comprehensive overview on "smart" targeting and drug delivery systemsUnderstanding of the biological identity of nanoparticles for drug delivery applicationsDetailed information on the legal framework for protection of pharmaceutical trade mark in Europe and the United States

Author : Thidarat Wongpinyochit
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.09/5 ( download)

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Download or read book Silk Nanoparticles for Drug Delivery Applications written by Thidarat Wongpinyochit and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Silk from Bombyx mori is being used in humans for loading applications due to its excellent mechanical properties and biocompatibility. Furthermore silk is emerging as potential biomaterial for biomedical applications such as drug delivery and tissue-engineering. The aim of this thesis was to examine the potential of silk nanoparticles for drug delivery by characterizing (1) particle size, (2) zeta potential, (3) stability, (4) loading efficiency and (5) in vitro drug release. First, silk nanoparticles were generated by a desolvation method using acetone. The resulting particle size and zeta potential were measured using dynamic light scattering, which revealed nano-sized particles (104.20 ± 1.70 nm) with narrow polydispersity index (0.11 ± 0.01), and negative surface charge (-56.38 ± 5.60 mV). In water silk nanoparticles were stable over 4 weeks over wide temperature range (4°C to 37°C). Second, nanoparticles were surface modified with polyethylene glycol (PEG) by reacting cyanuric chloride activated methoxypolyethylene glycol (5000 g/mol) with silk. The amount of activated PEG grafted to particle's surface was controlled by the weight ratio to silk nanoparticles, resulting in 19.39 ± 1.93% w/w conjugated PEG. The stability of PEGylated silk nanoparticles in water and in phosphate buffered saline at pH 7.4 was studied and compared with unmodified silk nanoparticles; PEGylated silk nanoparticles had a superior stability over the unmodified nanoparticles in phosphate buffered saline. Third, the drug loading and release behavior of silk nanoparticles and PEGylated silk nanoparticles was investigated with two model drugs; propranolol HCl and doxorubicin HCl. The native and PEGylated silk nanoparticles showed high encapsulation efficiency for doxorubicin HCl (100% w/w) and propranolol HCl (> 93% w/w). The release of doxorubicin HCl over 14 days was pH dependent, and showed highest release at pH 4.5 from native and PEGylated silk nanoparticles as compared to pH 6.0 and 7.4 (pH 4.5”6.0>7.4). PEGylation significantly impacted on the release behavior of doxorubicin HCl from silk nanoparticles by showing faster release at pH 4.5 and 6.0 in comparison to unmodified silk nanoparticles. In conclusion, silk nanoparticles and PEGylated silk nanoparticles showed promise as potential anticancer drug delivery systems and warrant future in vitro studies.

Author : Sougata Jana
Publisher : Springer Nature
ISBN 13 : 9811671524
Total Pages : 524 pages
Book Rating : 4.24/5 ( download)

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Download or read book Functional Biomaterials written by Sougata Jana and published by Springer Nature. This book was released on 2022-03-29 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores in depth a wide range of functional biomaterials-based systems for drug, gene delivery, and biomedical aspects. The chapters cover newer technologies such as polymeric micelle, pH-responsive biomaterials, stimuli-responsive hydrogels, silk fibroin, inorganic biomaterials, synthetic biomaterials, 3D printed biomaterials, metallic biomaterials, ceramic and hybrid biomaterials. It also describes the theranostic approaches for cancer therapy, the biomaterials-based nanofibers scaffolds in tissue engineering, as well as the strategies applications of metallic biomaterials for the medical and dental prosthetic field. This newer and updated approach will be attractive for biomedical engineering students working on materials science in the development of novel drug delivery strategies. The book will be an important reference for researchers and professionals working on biomaterial research in the pharmaceutical and medical fields.

Author : Raphael M. Ottenbrite
Publisher : CRC Press
ISBN 13 : 9781420010251
Total Pages : 332 pages
Book Rating : 4.55/5 ( download)

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Download or read book Polymeric Drugs and Drug Delivery Systems written by Raphael M. Ottenbrite and published by CRC Press. This book was released on 2019-04-30 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymeric materials are now playing an increasingly important role in pharmaceuticals, as well as in sensing devices, in situ prostheses and probes, and microparticle diagnostic agents. This new volume consists of twenty-two recent research-based reports on the developments in these areas of pharmaceutical and biomaterials technology. The reports w

Author : Yashwant V. Pathak
Publisher : John Wiley & Sons
ISBN 13 : 1118228898
Total Pages : 542 pages
Book Rating : 4.90/5 ( download)

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Download or read book Antibody-Mediated Drug Delivery Systems written by Yashwant V. Pathak and published by John Wiley & Sons. This book was released on 2012-04-17 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers various aspects of antibody mediated drug delivery systems – theoretical aspects, processing, viral and non-viral vectors, and fields where these systems find and /or are being evaluated for applications as therapeutics and diagnostic treatment. Chapters discuss actual applications of techniques used for formulation and characterization. Applications areas include cancer, pulmonary, ocular diseases; brain drug delivery; and vaccine delivery. The contributing authors represent over 10 different countries, covering recent developments happening around the globe.

Author : Ashim Mitra
Publisher : John Wiley & Sons
ISBN 13 : 1118662849
Total Pages : 844 pages
Book Rating : 4.47/5 ( download)

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Download or read book Advanced Drug Delivery written by Ashim Mitra and published by John Wiley & Sons. This book was released on 2013-08-26 with total page 844 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad range of human diseases. Advanced Drug Delivery features contributions from an international team of pharmaceutical scientists. Chapters reflect a thorough review and analysis of the literature as well as the authors' firsthand experience developing drug delivery systems. The book is divided into four parts: Part I, Introduction and Basics of Advanced Drug Delivery, explores physiological barriers, stability, transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offers tested and proven strategies for advanced delivery of both small molecules and macromolecules Part III, Translational Research of Advanced Drug Delivery, focuses on regulatory considerations and translational applications of advanced drug delivery systems for the treatment of cardiovascular diseases, cancer, sexually transmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery in Emerging Research Areas, examines stem cell research, cell-based therapeutics, tissue engineering, and molecular imaging Each chapter provides objectives and assessment questions to help readers grasp key concepts and assess their knowledge as they progress through the book. Advanced Drug Delivery is recommended for graduates and upper-level undergraduates in the pharmaceutical sciences who need a solid foundation in the basics. It is also recommended for pharmaceutical professionals who want to take advantage of new and emerging applications in advanced drug delivery systems.

Author : Juergen Siepmann
Publisher : Springer Science & Business Media
ISBN 13 : 1461408806
Total Pages : 593 pages
Book Rating : 4.02/5 ( download)

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Download or read book Fundamentals and Applications of Controlled Release Drug Delivery written by Juergen Siepmann and published by Springer Science & Business Media. This book was released on 2011-12-14 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pitched at a level comprehensible to those new to the field, this authoritative text covers the scientific and technological fundamentals of drug delivery as well as clinical applications and the developmental potential in controlled release drug delivery.

Author : Dennis M. Brown
Publisher : Springer Science & Business Media
ISBN 13 :
Total Pages : 408 pages
Book Rating : 4.71/5 ( download)

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Download or read book Drug Delivery Systems in Cancer Therapy written by Dennis M. Brown and published by Springer Science & Business Media. This book was released on 2004 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: A major difficulty in successfully treating cancer with drugs is achieving adequate drug concentrations in the diseased areas without overexposing drug-sensitive normal tissues. In a number of cases, specialized drug delivery systems are required to realize a therapeutic gain. In Drug Delivery Systems in Cancer Therapy, Dennis M. Brown has assembled a panel of leading experts to survey all the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. They also profile the use of novel formulation technologies-including synthetic polymers and biomaterials for sustained drug release to achieve greater therapeutic effect-that have demonstrated efficacy in a number of approved and late-stage clinical products. They also consider the benefits of, and future opportunities for, various drug delivery systems, as well as the experimental techniques used in their evaluation. Although the focus is primarily on small molecule delivery, many of the technologies described can also be effective in delivering larger biomolecules. Comprehensive, cutting-edge, and highly practical, Drug Delivery Systems in Cancer Therapy captures for experimental oncologists, medicinal chemists, and pharmacologists the universe of approaches, technologies, and systems available for substantially enhancing the therapeutic outcome of anticancer drug delivery today.

Author : Prashant Kesharwani
Publisher : Academic Press
ISBN 13 : 0128163674
Total Pages : 340 pages
Book Rating : 4.72/5 ( download)

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Download or read book Nanotechnology-Based Targeted Drug Delivery Systems for Lung Cancer written by Prashant Kesharwani and published by Academic Press. This book was released on 2019-01-26 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology-based Targeted Drug Delivery Systems for Lung Cancer is an indispensable resource that will help pharmaceutical scientists and clinical researchers design and develop novel drug delivery systems and devices for the treatment of lung cancer. As recent breakthroughs in nanomedicine are now making it possible to deliver drugs, genes and therapeutic agents to localized areas of disease to maximize clinical benefit, while also limiting unwanted side effects, this book explores promising approaches for the diagnosis and treatment of lung cancer using cutting-edge nanomedical technologies. Topics discussed include polymeric nanoparticles, solid lipid nanoparticles, liposomes, dendrimers, micelles and nanoemulsions. Provides an overview of an array of nanotechnology-based drug delivery systems Examines the design, synthesis and application of different nanocarriers in drug and gene delivery Provides an in-depth understanding of the design of targeted nanotherapeutics and technologies and its implication in various site-specific cancers